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An emulsifier system for experimental intravenous fat emulsions
Author(s) -
Singleton W. S.,
White J. L.,
DiTrapani L. L.,
Brown M. L.
Publication year - 1962
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02631706
Subject(s) - polyethylene glycol , chromatography , chemistry , acetone , emulsion , fractionation , tartaric acid , isotonic , glyceride , organic chemistry , fatty acid , citric acid , medicine
An emulsifying system for a fat emulsion which has been very satisfactory for intravenous administration to dogs has been developed. The emulsion contained cottonseed oil (15%), polyethylene glycol monopalmitate (1.2%), tartaric acid ester of monoglycerides (0.3%), and polyoxyethylene‐polyoxypropylene (0.3%), in isotonic dextrose solution. The polyethylene glycol monopalmitate was isolated from laboratory and commercial esterification reaction mixtures of monoester, diester, and nonreacted polyethylene glycol. Washing with NaCl solution removed nonreacted glycol, and fractionation in acetone separated the mono‐ and di‐esters, the diester separating as a solid. Analytical methods were applied to characterize all fractions, and to determine the reproducibility of composition of successive batches. The monopalmitates from both laboratory and commercial preparations were similar in properties. The tartaric ester of monoglycerides was washed with NaCl solution and fractionated in acetone. The liquid portion was recovered and used for emulsification. Emulsions prepared with the fractionated emulsifiers appear to give satisfactory physiologic results when infused in dogs.