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Hepatic participation in lipid metabolism
Author(s) -
Di Luzio N. R.
Publication year - 1960
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02631218
Subject(s) - parenchyma , triglyceride , excretory system , kupffer cell , lipid metabolism , cholesterol , metabolism , cell , distribution (mathematics) , medicine , endocrinology , mononuclear phagocyte system , biology , cell function , chemistry , pathology , biochemistry , immunology , mathematical analysis , mathematics
Summary and Conclusions During alimentary lipemia induced in dogs by the feeding of saturated or unsaturated fats no significant alteration occurred in phagocytic function as indicated by colloidal carbon removal and colloidal gold tissue distribution studies. The cellular distribution of intravenously administered triglyceride indicated that most of the injected triglyceride was found in the isolated hepatic parenchymal cell. The distribution of an intravenously administered free cholesterol emulsion indicated initial localization in the parenchymal cell and a later elevation in the Kupffer cell. These findings suggest that both hepatic parenchymal and Kupffer cells participate in the removal of chylomicra; the parenchymal cell has the greatest role. The late elevation in cholesterol content of the Kupffer cell is indicative of a metabolic or excretory function of these cells in cholesterol metabolism.