Premium
Gas chromatography of the fat‐soluble vitamins: A review
Author(s) -
Sheppard A. J.,
Prosser A. R.,
Hubbard W. D.
Publication year - 1972
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02609374
Subject(s) - menadione , sodium bisulfite , fat soluble vitamin , chromatography , chemistry , vitamin , gas chromatography , biochemistry , organic chemistry , enzyme
The application of gas liquid chromatography (GLC) as an analytical tool for the determination of the fat‐soluble vitamins A, D, E and K has yet to be utilized to its full potential. A review of the published work of many researchers in this field is presented. GLC methods to measure the vitamin A isomers have not been developed to any appreciable practical extent. Liquid liquid chromatography might well be the technique of choice. In the field of vitamin D there are indications that a practical GLC analysis is feasible for pharmaceutical preparations. The GLC applications for vitamin E are diverse, well defined and generally widely accepted in research laboratory situations and for regulatory and quality control usage. Vitamins K 1 and K 2 have been measured with limited success in a few research laboratories, but the GLC methods have not developed on a practical basis. However GLC is used for measuring vitamin K 3 (menadione and menadione sodium bisulfite) on a fairly routine basis in quality control laboratories.