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Regulation of the biosynthesis of 22:5n‐6 and 22:6n‐3: A complex intracellular process
Author(s) -
Sprecher Howard,
Chen Qi,
Yin Feng Qin
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02562271
Subject(s) - endoplasmic reticulum , peroxisome , biosynthesis , microsome , clinical chemistry , intracellular , lipidology , biochemistry , fatty acid , biology , lipid metabolism , lipid droplet , mitochondrion , chemistry , in vitro , enzyme , gene
Both 22:4n‐6 and 22:5n‐3 are synthesized from n‐6 and n‐3 fatty acid precursors in the endoplasmic reticulum. The synthesis of both 22:5n‐6 and 22:6n‐3 requires that 22:4n‐6 and 22:5n‐3 are metabolized, respectively, to 24:5n‐6 and 24:6n‐3 in the endoplasmic reticulum. These two 24‐carbon acids must then move to peroxisomes for partial degradation followed by the movement of 22:5n‐6 and 22:6n‐3 back to the endoplasmic reticulum for use as substrates in membrane lipid biosynthesis. Clearly an understanding of the control of intracellular fatty acid movement as well as of the reactions carried out by microsomes, peroxisomes, and mitochondria are all required in order to understand not only what regulates the biosynthesis of 22:5n‐6 and 22:6n‐3 but also why most tissue lipids selectively accumulate 22:6n‐3.