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A chronic ethanol‐feeding study in rhesus monkeys
Author(s) -
Pawlosky Robert J.,
Salem Norman
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02562261
Subject(s) - lipidology , alcohol , clinical chemistry , calorie , ethanol , chemistry , medicine , fatty alcohol , liquid diet , endocrinology , blood plasma , blood alcohol , absorption (acoustics) , biochemistry , food science , biology , poison control , environmental health , injury prevention , physics , acoustics
This study describes the effect of chronic ethanol‐feeding in rhesus monkeys. Animals which were maintained on a diet containing 18:2n‐6 and 18:3n‐3 as 1.4 and 0.08% of the calories, respectively, and consumed alcohol (mean 2.6 g kg −1 d −1 ) had decreased amounts of 20:4n‐6 and 22:6n‐3 in their livers and plasma lipids compared with controls. Alcohol consumption did not appear to effect the absorption of 2 H 5 ‐18:2n‐6 and 18:3n‐3 esters into the blood following an oral dose. There was an increase in 2 H 5 enrichment in plasma 20:4n‐6 and 22:6n‐3, indicating that alcohol may have increased production of these fatty acids. There was a greater concentration of 4‐hydroxynonenal in the plasma of alcohol‐exposed monkeys compared to controls.