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New developments in phospholipase A 2
Author(s) -
Chaminade Brigitte,
Le Balle François,
Fourcade Olivier,
Nauze Michel,
Delagebeaudeuf Claire,
GassamaDiagne Ama,
Simon MarieFrançoise,
Fauvel Josette,
Chap Hugues
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02562228
Subject(s) - phospholipase , phospholipase a2 , proinflammatory cytokine , biology , cytosol , microbiology and biotechnology , function (biology) , epididymis , transgene , phospholipase a , gene , enzyme , biochemistry , chemistry , genetics , immunology , inflammation , sperm
Some of the most recent data concerning various phospholipases A 2 , with special emphasis on secretory, cytosolic, and calcium‐independent phospholipases A 2 are summarized. Besides their contribution to the production of proinflammatory lipid mediators, the involvement of these enzymes in key cell responses such as apoptosis or tumor cell metastatic potential is also discussed, taking advantage of transgenic models based on gene invalidation by homologous recombination. The possible role of secretory and cytosolic platelet‐activating factor acetyl hydrolases is also briefly mentioned. Finally, the ectopic expression in epididymis of an intestinal phospholipase B opens some novel issues as to the possible function of phospholipases in reproduction.