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Essentiality of fatty acids
Author(s) -
Spector Arthur A.
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02562220
Subject(s) - polyunsaturated fatty acid , docosahexaenoic acid , arachidonic acid , biochemistry , eicosapentaenoic acid , eicosanoid , fatty acid , chemistry , thromboxanes , biology , metabolism , essential nutrient , enzyme , organic chemistry , nutrient
All fatty acids have important functions, but the term “essential” is applied only to those polyunsaturated fatty acids (PUFA) that are necessary for good health and cannot be completely synthesized in the body. The need for arachidonic acid, which is utilized for eicosanoid synthesis and is a constituent of membrane phospholipids involved in signal transduction, is the main reason why the n‐6 class of PUFA are essential. Physiological data indicate that n‐3 PUFA also are essential. Although eicosapentaenoic acid also is a substrate for eicosanoid synthesis, docosahexaenoic acid (DHA) is more likely to be the essential n‐3 constituent because it is necessary for optimal visual acuity and neural development. DHA is present in large amounts in the ethanolamine and serine phospholipids, suggesting that its function involves membrane structure. Because the metabolism of n‐6 PUFA is geared primarily to produce arachidonic acid, only small amounts of 22‐carbon n‐6 PUFA are ordinarily formed. Thus, the essentiality of n‐3 PUFA may be due to their ability to supply enough 22‐carbon PUFA for optimal membrane function rather than to a unique biochemical property of DHA.