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Activity of fatty acyl CoA‐lysophospholipid acyltransferases in liver microsomes of rats fed a choline‐deficient diet
Author(s) -
Chen S. H.,
Lombardi B.
Publication year - 1973
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02544628
Subject(s) - acyltransferases , choline , lipidology , microsome , clinical chemistry , acyl coa , biochemistry , chemistry , enzyme , biosynthesis
Feeding a choline‐deficient diet to rats has no effect on the activity of fatty acyl CoA‐lysophospholipid acyltransferases, even though liver microsomes are severely depleted of lecithins. Thus lecithins appear to have no functional role in the activity of these transferases. It can be excluded that the latter enzymes are involved in the production of the changes in the fatty acid composition of liver phospholipids occurring in choline‐deficient rats. These changes result most likely from alterations in the biosynthesis of liver lecithins and cephalins.