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Feeding pure docosahexaenoate or arachidonate decreases plasma triacylglycerol secretion in rats
Author(s) -
Williams M. A.,
Tinoco J.,
Yang Y. T.,
Bird M. I.,
Hincenbergs I.
Publication year - 1989
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02544579
Subject(s) - lipidology , lipogenesis , medicine , clinical chemistry , endocrinology , secretion , essential fatty acid , chemistry , phospholipid , biology , fatty acid , polyunsaturated fatty acid , biochemistry , metabolism , membrane
Essential fatty acid (EFA)‐deficient rats were fed highly purified methyl esters of docosahexaenoate (22∶6n−3), arachidonate (20∶4n−6), alpha‐linolenate (18∶3n−3) or oleate (18∶1n−9) (100 mg/day, tube fed for 3–10 days), and their plasma triacylglycerol (TG) secretion rates were measured. Secretion rates of TG into plasma were reduced by tube‐feeding 22∶6n−3, 20∶4n−6, 18∶3n−3, but not 18∶1n−9, to EFA‐deficient rats. A significant reduction occurred after feeding 22∶6n−3 for only three days. Feeding 22∶6n−3 or 18∶3n−3 to EFA‐deficient rats for three days also reduced the activities of liver lipogenic enzymes and sharply increased the proportions of 22∶6n−3 and 20∶5n−3 in liver phospholipid fractions. Mechanisms by which these EFA may reduce lipogenesis are discussed.