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Elevated levels of nonesterified fatty acids in the myocardium of alloxan diabetic rats
Author(s) -
Chattopadhyay Jyotiprakas,
Thompson Ed W.,
Schmid Harald H. O.
Publication year - 1990
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02544338
Subject(s) - nefa , medicine , lipidology , endocrinology , clinical chemistry , alloxan , docosahexaenoic acid , diabetes mellitus , chemistry , fatty acid , arachidonic acid , insulin , polyunsaturated fatty acid , biochemistry , enzyme
Myocardial nonesterified fatty acids (NEFA) increase markedly within the first two days after the induction of insulin‐dependent diabetes mellitus in rats by intravenous injection of alloxan. After initial variability, NEFA levels in diabetic hearets remain constant at approximately 450 nmol/g tissue (16 nmol/gmmol lipid P), which is about three times higher than that in control hearts. Nonesterified linoleic acid is significantly increased in diabetic heart whereas both arachidonic and docosahexaenoic acids are decreased compared to controls.