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Increased liver lipase activity in rats with essential fatty acid deficiency
Author(s) -
Schoonderwoerd Kees,
Hülsmann Willem C.,
Jansen Hans
Publication year - 1989
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02544076
Subject(s) - lipase , clinical chemistry , medicine , endocrinology , lipidology , prostaglandin , chemistry , enzyme assay , biology , enzyme , biochemistry
Liver lipase activity was measured in EFA‐deficient rats (long‐term) and in control rats and rats fed an EFA‐deficient diet for two weeks (short‐term). Liver lipase activity was significantly enhanced by EFA deficiency, both in long‐term and short‐term experiments. The enhanced liver lipase activity could be normalized by feeding these rats normal laboratory chow for 14 days. Since during EFA deficiency prostaglandin synthesis is impaired, the possible involvement of prostaglandins in the observed changes in liver lipase actvity during EFA deficiency was studied. Administration of the prostaglandin synthesis inhibitor indomethacin (5 mg/kg body weight, i.p.) to normally fed rats for two days led to an increase of liver lipase activity. Prostaglandin E 2 was found to inhibit the secretion of liver lipase activity by freshly isolated parenchymal liver cells in vitro . These results indicate that the increase in liver lipase activity during EFA deficiency may be due to an impairment of the prostaglandin synthesis.