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Effects of oleic, arachidonic and 5,8,11,14‐nonadecatetraenoic acids on lipid secretion and ketogenesis in perfused rat liver
Author(s) -
Ikeda Ikuo,
Murakami Jun,
Oka Takayuki,
Sugano Michihiro,
Yamada Hideaki,
Shimizu Sakayu,
Kawashima Hiroshi,
Shinmen Yoshifumi,
Amachi Teruo
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02544020
Subject(s) - ketogenesis , lipidology , clinical chemistry , arachidonic acid , oleic acid , secretion , chemistry , glyceride , biochemistry , medicine , endocrinology , ketone bodies , biology , metabolism , fatty acid , enzyme
The effects of perfused oleic (18∶1n−9), arachidonic (20∶4n−6) and 5,8,11,14‐nonadecatetraenoic (19∶4n−5) acids on triglyceride and cholesterol secretion and ketone body production were studied in isolated rat liver. As compared to oleic and 19∶4n−5 acids, both ketone body production and triglyceride secretion were significantly lowered when arachidonic acid was perfused. The concentration of triglyceride in the post‐perfused liver was lower upon perfusion with arachidonic acid than upon perfusion with oleic acid or 19∶4n−5 acid. Cholesterol secretion in the liver perfused with arachidonic acid or 19∶4n−5 acid was significantly higher than with oleic acid. The concentration of cholesterol in the post‐perfused liver was slightly but significantly higher with 19∶4n−5 acid than with the other fatty acids. The results suggest that 19∶4n−5 acid when compared with arachidonic acid affects lipid metabolism in liver differently.