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Change in bile salt dependent lipase in human breast milk during extended lactation
Author(s) -
Dupuy Patricia,
Frédéric Saunière J.,
Vis Henry L.,
Leclaire Michèle,
Lombardo Dominique
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02544007
Subject(s) - lactation , lactose , lipase , breast milk , food science , esterase , breastfeeding , biology , medicine , chemistry , endocrinology , zoology , biochemistry , pregnancy , enzyme , genetics , pathology
Two hundred eighty‐one milk samples collected from Zaïrian nonprivileged, undernourished mothers, in series of nine groups from 1 month to 18 months after parturition, and 66 milk samples collected from French privileged mothers in series of four groups from 2 days to 16 months postpartum , were analyzed for their lactose, lipid and protein contents. In addition, the activity of bile salt‐dependent lipase (esterase), which may play an important role in the newborn infant's lipids digestion, was measured. After the first month postpartum , independent of the nutritional state of the mother, sugar and protein concentrations were identical. Lipid content of French mother's milk was lower in transitional milk, but appeared constant in mature milk with an average value of 29.1±5.8 mg/mL of milk. In Zarärian mother's milk, the lipid content of mature milk plateaued at around 50–55 mg/mL independent of the stage of lactation. Bile salt‐dependent lipase showed constant esterase activity within the lactation stage in privileged mother's milk, but decreased by almost 80–90% during the first four months of lactation in undernourished mothers. The data suggest that milk from nonprivileged mothers may lose some of its ability of hydrolyze milk lipid esters, which could also be of consequence to the infant's normal growth in view of its effect on the esters of the lipid‐soluble vitamins A, E and D.