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The effect of lysophosphatidylcholine on coronary and renal circulation in the rabbit
Author(s) -
Wolf A.,
Saito T.,
Dudek R.,
Bing R. J.
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02543975
Subject(s) - lysophosphatidylcholine , medicine , cardiology , renal blood flow , contractility , blood flow , coronary circulation , vascular resistance , renal circulation , blood pressure , coronary vasodilator , chemistry , phospholipid , biochemistry , membrane , phosphatidylcholine
It has been shown that different lysophosphatidylcholines (LPC) possess relaxing properties in vascular strips. We report on the effect of intraatrial injection of LPC micelles into white New Zealand rabbits. Changes in renal and coronary flow were determined by radioactive microspheres. Coronary blood flow increased significantly following administration of LPC, while no significant changes were observed in renal blood flow, cardiac output and myocardial contractility. Coronary, renal and total vascular resistance, as well as mean arterial pressure, dropped significantly. Cardiac arrhythmia and hemolysis were not noted. The results demonstrate the vasorelaxant effect of LPC in vivo .