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The metabolism of polyenoic fatty acids
Author(s) -
Klenk E.
Publication year - 1965
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02541293
Subject(s) - linolenate , double bond , carbon atom , chemistry , metabolism , fatty acid , stereochemistry , biochemistry , organic chemistry , ring (chemistry)
Abstract Feeding experiments with C 14 ‐labeled and unlabeled unsaturated fatty acids have been used to study the possible routes of formation of the C 20 ‐ and C 22 ‐polyenoic fatty acids of rat liver phosphatides. The acids of the palmitoleate, oleate, linoleate, and linolenate types (considered on the basis of the position of the double bond closest to the methyl end) are apparently formed from the C 16 and C 18 unsaturated acids of the corresponding types. The results rule out possible transformations of the C 20 ‐ and C 22 ‐polyenoic acids from one type to another, and demonstrate the exclusive introduction of new double bonds toward the carboxyl group. Isomers of linoleate or linolenate in which the double bonds were shifted by one carbon atom toward the carboxyl or methyl groups were incorporated into the phosphatides only to a negligible extent in the form of polyenoic acids.