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Microbial transformation of 12‐hydroxyoctadecanoic acid to 5‐ n ‐hexyl‐tetrahydrofuran‐2‐acetic acid
Author(s) -
Huang J. K.,
Keudell K. C.,
Zhao J.,
Klopfenstein W. E.,
Wen L.,
Bagby M. O.,
Lanser A. C.,
Plattner R. D.,
Peterson R. E.,
Abbott T. P.,
Weisleder D.
Publication year - 1995
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02541090
Subject(s) - tetrahydrofuran , acetic acid , chemistry , incubation , organic chemistry , nuclear chemistry , biochemistry , solvent
Abstract Stationary‐phase cells of a corynebacterium (FUI‐2) and a bacillus (NRRL B‐14864) isolate, when grown aerobically in 1% YE medium at 25°C, converted 12‐hydroxystearic acid to a major compound, 5‐ n ‐hexyl‐tetrahydrofuran‐2‐acetic acid, and other intermediate and minor compounds (6‐hydroxydodecanoic acid, 4‐hydroxydecanoic acid, 4‐ketodecanoic acid and γ‐decanolactone). The yields of 5‐ n ‐hexyl‐tetrahydrofuran‐2‐acetic acid, 4‐hydroxydecanoic acid, and γ‐decanolactone, by Bacillus lentus NRRL B‐14864 were 43%, 18% and 5%, respectively, after 2.5 d of incubation.