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A lipid mobilizing factor in serum of tumor‐bearing mice
Author(s) -
Kitada S.,
Hays E. F.,
Mead J. F.
Publication year - 1980
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02540964
Subject(s) - clinical chemistry , lipidology , adipose tissue , endocrinology , medicine , linoleic acid , biology , neoplasm , respiratory system , chemistry , fatty acid , biochemistry , genetics
There is considerable evidence that the growing tumor requires a source of unsaturated fatty acids, but the nature of this source and the mechanism of mobilizing the fatty acids from it are obscure. These experiments make use of AKR mice with implanted adipose tisue labeled with 1‐ 14 C linoleic acid. With this experimental animal, it has been found that: (a) in the normal, fed mouse, fat is mobilized slowly and appears largely as respiratory CO 2 , following oxidation, (b) in the normal, fasted mouse, fat is mobilized rapidly and appears largely as respiratory CO 2 ; (c) in the tumor‐bearing, fed mouse, fat is mobilized rapidly and appears largely in the tumor; and (d) the serum from tumor‐bearin mice, when injected into normal mice, produces an immediate massive fat mobilization that does not respond to feeding, whereas the serum from normal, fed mice does not. It is concluded that a mobilizing factor of unknown nature is present in the serum of tumor‐bearing AKR mice.