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Novel derivatives of methyl hexahydro‐3‐methyl‐6‐thioxo‐1,2,4,5‐tetrazine‐3‐nonanoate
Author(s) -
Saeed M. T.,
Mustafa J.,
Rauf A.,
Osman S. M.
Publication year - 1992
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02540954
Subject(s) - tetrazine , chemistry , medicinal chemistry , organic chemistry
Methyl hexahydro‐3‐methyl‐6‐thioxo‐1,2,4,5‐tetrazine‐3‐nonanoate (I) on treatment with reagents such as chloroacetic acid, 1,2‐dibromoethane and 2‐mercaptoethanol under different reaction conditions afforded methyl 3,4,6,7‐tetrahydro‐3‐methyl‐6‐oxo‐2 H ‐thiazolo[3,2‐b]‐1,2,4,5‐tetrazine‐3‐nonanoate (II), methyl 3,4,6,7‐tetrahydro‐3‐methyl‐2 H ‐thiazolo[3,2‐b]‐1,2,4,5‐tetrazine‐3‐nonanoate (III) and methyl 8‐methyl‐1‐oxa‐4‐thia‐6,7,9,10‐tetraazaspiro‐[4.5]‐decane‐8‐nonanoate (IV) in good yields. The structures of compounds II–IV were established by elemental analysis, infrared (IR), nuclear magnetic resonance (NMR), and mass spectral data.