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Lipid peroxide catalyzed chemical carcinogenesis
Author(s) -
O'Brien Peter J.
Publication year - 1984
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02540829
Subject(s) - chemistry , acetylation , microsome , biochemistry , lipid peroxidation , peroxidase , hydrogen peroxide , oxidase test , peroxide , carcinogen , catalysis , dna , enzyme , organic chemistry , gene
Peroxides, including lipid peroxides, with heme catalysts cause the binding of C 14 ‐acetylaminofluorene to DNA if microsomes are present. This binding was 96% inhibited by paraoxon, a deacetylase inhibitor. It is concluded that peroxide‐peroxidase systems rapidly oxidize acetylated arylamines to proximate carcinogens following deacetylation by microsomal deacetylases. The DNA binding observed was greater than that observed with the liver microsomal mixed function oxidase catalyzed activation to N‐OH‐acetylaminofluorene, which binds to DNA following deacetylation by microsomal deacetylase. Lipid peroxidation or prostaglandin synthesis should therefore enhance carcinogenesis induced by arylamides.