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Resolution of vic ‐dihydroxy acid diastereomers to four enantiomers by high‐performance liquid chromatography
Author(s) -
Takagi Toru
Publication year - 1994
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02540672
Subject(s) - diastereomer , enantiomer , ethylamine , resolution (logic) , chromatography , chemistry , high performance liquid chromatography , chiral derivatizing agent , chiral stationary phase , proline , chiral column chromatography , organic chemistry , amino acid , biochemistry , artificial intelligence , computer science
A chromatographic method is described for resolution of 9,10‐ vic ‐dihydroxyoctadecanoic acid. The threo and erythro isomers are both resolved into two enantiomers as di‐3,5‐dinitrophenylurethane derivatives by chiral‐phase highperformance liquid chromatography on ( S )‐proline, ( R )‐1‐(α‐naphthyl) ethylamine stationary phase. Simultaneous separation of the threo and erythro dihydroxy acid mixtures to the four enantiomers is possible by this method.