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Studies on the stability of Kathon ® CG/ICP Microbicide in alpha olefin sulfonate Based systems
Author(s) -
Ferm Donald J.,
Griffin T. Scott
Publication year - 1990
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02540638
Subject(s) - chemistry , microbicide , chromatography , hypochlorite , sulfite , bisulfite , organic chemistry , biochemistry , human immunodeficiency virus (hiv) , medicine , family medicine , gene expression , dna methylation , gene
Kathon ® CG/ICP Microbicide (Rohm & Haas Co.) which contains 1.5% 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one and 0.35% 2‐methyl‐4‐isothiazolin‐3‐one as active ingredients has been found to be a highly efficient antimicrobial preservative for formulated products. However, its use has been contra‐indicated for formulations containing certain anionic surfactants, especially AOS, because of the suspected presence of residual bisulfite ion added to remove residual hypochlorite remaining at the end of the bleaching process. It has been found that sulfite ion is not stable in the complex mixture of components in commercially produced AOS. AOS samples tested, whether bleached or not, contained residual reducing capacity, but of a sufficiently low redox potential as to not affect Kathon ® CG/ICP Microbicide stability. Alternative analytical methods for analysis for bisulfite in AOS and other surfactant systems are discussed. A new HPLC method for determination of Kathon ® CG/ICP Microbicide level in formulated products was developed.