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Lack of regression of preestablished gallstones in mice
Author(s) -
Beynen Anton C.
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02540373
Subject(s) - cholic acid , gallstones , cholesterol , medicine , clinical chemistry , lipidology , endocrinology , chenodeoxycholic acid , bile acid , chemistry
Feeding a high cholesterol, high cholic acid diet to mice for 28 days caused increased concentrations of plasma and liver cholesterol and formation of gallstones. Removal of cholesterol and cholic acid from the diet led to normalization of plasma and liver cholesterol within 28 days. Regression of the preestablished gallstones did not occur within 107 days.