Premium
Effect of cholestyramine on bile acid metabolism in conventional rats
Author(s) -
Imai Yasuharu,
Kawata Sumio,
Inada Masami,
Miyoshi Shio,
Minami Yuzo,
Matsuzawa Yuji,
Uchida Kiyohisa,
Tarui Seiichiro
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02540367
Subject(s) - cholestyramine , chenodeoxycholic acid , medicine , bile acid , cholic acid , cholesterol , endocrinology , enterohepatic circulation , chemistry , bile acid malabsorption , feces , excretion , biology , microbiology and biotechnology
Effects of cholestyramine on biliary secretion of cholesterol, phospholipids and bile acids and fecal excretion of sterols and bile acids were examined in Wistar male rats. Six rats were fed a basal diet, and the other six were fed a basal diet supplemented with 5% cholestyramine for eight days. Bile flow and biliary secretion of bile acids and phospholipids (per hour per rat) decreased with cholestyramine treatment, while biliary cholesterol secretion (per hour per rat) remained unchanged. In the biliary bile acid composition, a marked increase of chenodeoxycholic acid with a concomitant decrease of β‐muricholic acid was observed in cholestyramine‐treated rats. Fecal excretion of total sterols and bile acids increased about three‐and four‐fold, respectively, after cholestyramine treatment. The increase of fecal bile acids derived from cholic acid was more predominant than that derived from chenodeoxylcholic acid, resulting in an increase of the cholic acid group/chenodeoxycholic acid group ratio.