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Effect of essential fatty acid deficiency on myelin proteins
Author(s) -
Miller Sheldon L.,
Klurfeld David M.,
Loftus Bernadette,
Kritchevsky David
Publication year - 1984
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537414
Subject(s) - myelin , lipidology , clinical chemistry , phospholipid , endocrinology , biochemistry , medicine , fatty acid , myelin basic protein , leucine , biology , chemistry , central nervous system , amino acid , membrane
The effect of essential fatty acid (EFA) deficiency on rat‐brain myelin proteins was studied. Rats were maintained on a lipid‐free diet and compared with control rats fed the same diet supplemented with 3% corn oil. At 17 days of age, each pup was injected with [ 3 H]leucine and rats from each group were killed over a period of 163 days. Although a large decrease occurred in the total amount of myelin protein per brain, the proportions of constituent myelin proteins remained relatively unchanged. Metabolic studies showed a decrease in the net turnover of myelin proteins analogous to that previously demonstrated for myelin phospholipid (PL).