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Metabolism of 2( RS ),3‐epiminosqualene to 24( RS ),25‐epiminolanosterol by Gibberella fujikuroi
Author(s) -
Nes W. David,
Parish Edward J.
Publication year - 1988
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537354
Subject(s) - gibberella fujikuroi , lanosterol , clinical chemistry , biology , stereochemistry , biochemistry , chemistry , botany , sterol , gibberellin , cholesterol
The metabolic fate of 2( RS ),3‐epiminosqualene (Isq.), a demonstrable inhibitor of the 2,3‐oxidosqualene‐lanosterol cyclase, has been studied in Gibberella fujikuroi . The fungus transforms Isq. to a tetracyclic product for which the 24( RS ),25‐epiminolanosterol (EL) formulation was indicated by chromatographic and spectral data. The results are consistent with the pathway: Isq.→2,3‐imino‐22, 23‐oxidosqualene→EL.
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