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Malondialdehyde excretion by subjects consuming cod liver oil vs a concentrate of n‐3 fatty acids
Author(s) -
Piche L. A.,
Draper H. H.,
Cole P. D.
Publication year - 1988
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537352
Subject(s) - malondialdehyde , lipid peroxidation , chemistry , lipidology , food science , propyl gallate , clinical chemistry , fish oil , vitamin e , cod liver oil , excretion , biochemistry , antioxidant , fish <actinopterygii> , biology , fishery
Urinary malondialdehyde (MDA), an indicator of lipid peroxidation in the diat and in the tissues, was determined in human adults consuming a supplement of n‐3 fatty acids derived from a pharmaceutical grade of cod liver oil (CLO) without added antioxidants vs a concentrate of n‐3 acids containing dodecyl gallate and vitamin E. MDA excretion increased immediately in the subjects consuming CLO but remained unchanged in those ingesting the concentrate for 50 days. The increase in the subjects taking CLO was attributable to MDA in the oil. The results indicate that consuming unstabilized fish oils as a source of n‐3 fatty acids may entail exposure to potentially toxic products of lipid peroxidation.