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Platelet changes after a saturated fat meal and their prevention by dazmegrel, a thromboxane synthetase inhibitor
Author(s) -
Belch J. J. F.,
Saniabadi A. R.,
McLaughlin K.,
Forbes C. D.
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537296
Subject(s) - antithrombotic , meal , platelet , lipidology , medicine , platelet activation , clinical chemistry , thromboxane , endocrinology , chemistry
A saturated fat meal was given to 10 normal males both before and after pretreatment with UK38,485, a thromboxane synthetase inhibitor (Dazmegrel, Pfizer Central Research, Sandwich, Kent, United Kingdom). Following the fat meal at 2 and 4 hr there was laboratory evidence of platelet activation. Dazmegrel lowered baseline platelet activity and lessened platelet activation following the fat meal. This drug should be investigated further as a potential antithrombotic agent.