Platelet changes after a saturated fat meal and their prevention by dazmegrel, a thromboxane synthetase inhibitor | Zendy

Belch J. J. F. | Zendy; Saniabadi A. R. | Zendy; McLaughlin K. | Zendy; Forbes C. D. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Platelet changes after a saturated fat meal and their prevention by dazmegrel, a thromboxane synthetase inhibitor

Author(s) -

Belch J. J. F.,

Saniabadi A. R.,

McLaughlin K.,

Forbes C. D.

Publication year - 1987

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/bf02537296

Subject(s) - antithrombotic , meal , platelet , lipidology , medicine , platelet activation , clinical chemistry , thromboxane , endocrinology , chemistry

A saturated fat meal was given to 10 normal males both before and after pretreatment with UK38,485, a thromboxane synthetase inhibitor (Dazmegrel, Pfizer Central Research, Sandwich, Kent, United Kingdom). Following the fat meal at 2 and 4 hr there was laboratory evidence of platelet activation. Dazmegrel lowered baseline platelet activity and lessened platelet activation following the fat meal. This drug should be investigated further as a potential antithrombotic agent.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research