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Derivatization of keto fatty acids, X: Synthesis of thiazanones
Author(s) -
Khan Amjadullah,
Husain S. Rafat,
Ahmad F.,
Siddiqui M. S.,
Pimlott W.
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537284
Subject(s) - lipidology , derivatization , clinical chemistry , neurochemistry , chemistry , organic chemistry , chromatography , polyunsaturated fatty acid , fatty acid , biochemistry , biology , high performance liquid chromatography , neurology , neuroscience
The synthesis of alkyl chain‐substituted thiazanones from oxo fatty esters and a long chain aldehyde is reported. Four oxo compounds—methyl 10‐oxoundecanoate, methyl 9‐oxooctadecanoate, methyl 9,10‐dioxooctadecanoate and octadecanal—were allowed to react with β‐mercaptopropionic acid in the presence of ammonium carbonate in benzene to give the corresponding 4‐ m ‐thiazanones in high yields. The structures of these compounds were confirmed by combustion and spectral data.