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Alteration of hepatic phospholipids in rats and mice by feeding di‐(2‐ethylhexyl)adipate and di‐(2‐ethylhexyl)phthalate
Author(s) -
Yanagita Teruyoshi,
Satoh Mikinobu,
Nomura Hisashi,
Enomoto Noriyuki,
Sugano Michihiro
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537283
Subject(s) - phthalate , adipate , chemistry , docosahexaenoic acid , phosphatidylethanolamine , phosphatidylcholine , arachidonic acid , lipidology , dibutyl phthalate , biochemistry , plasticizer , oleic acid , polyunsaturated fatty acid , fatty acid , chromatography , phospholipid , organic chemistry , membrane , polymer chemistry , enzyme
Effects of di‐(2‐ethylhexyl)adipate (DOA) and di‐(2‐ethylhexyl)phthalate (DEHP), plasticizers for polyvinylchloride products, on concentrations and compositions of hepatic phospholipids were studied in rats. When administered to rats at a 2% level for 2 wk, both DOA and DEHP caused a hepatomegaly, an increase in hepatic phospholipids and a decrease in the ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE). In the comparable study with mice, the alkyl moiety of DOA was found to be responsible for these alterations. DOA and DEHP specifically altered fatty acid compositions of PC and PE: there was an increase in oleic and palmitic acids and a decrease in stearic and docosahexaenoic acids in PC and an increase in arachidonic acid at the expense of docosahexaenoic acid in PE. In addition, DOA caused an increase in the trienoic and tetraenoic molecular species in PC and an increase in the 1‐palmitoyl‐2‐arachidonyl (16∶0//20∶4) species in PE. Thus, the effects of DOA on the lipid dynamics resembled those observed with DEHP, although the magnitude was slightly moderated.