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Effects of triton WR 1339 and orotic acid on lipid metabolism in rats
Author(s) -
Takeuchi Nozomu,
Murase Mitsuharu,
Nomura Yasuharu,
Takase Haruto,
Uchida Kiyohisa
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537282
Subject(s) - chenodeoxycholic acid , clinical chemistry , medicine , cholesterol , chemistry , cholic acid , bile acid , lipidology , lipoprotein , orotic acid , lipid metabolism , biochemistry , endocrinology , biology
In order to investigate the effect of hepatic cholesterol flux on biliary bile acids, Triton WR 1339 and orotic acid were administered to rats, and the biliary cholesterol, phospholipids and bile acids were analyzed together with serum lipoproteins and hepatic lipids. Triton, which raised serum very low density lipoprotein and lipid levels and decreased serum high density lipoprotein liver lipid levels, increase the biliary cholic acid group/chenodeoxycholic acid group ratio (CA/CDCA) in the bile without affecting the total amount of bile acids and the other biliary lipids. Orotic acid, which decreased serum lipid and lipoprotein concentrations and increased liver lipid levels, increased the biliary excretion of cholesterol and phospholipids, but produced no significant change in the total amount of bile acids and in the CA/CDCA ratio in bile.