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Selective use of palmitic acid over stearic acid for synthesis of phosphatidylcholine and phosphatidylglycerol in lung
Author(s) -
Tsao Francis H. C.
Publication year - 1986
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537249
Subject(s) - stearic acid , phosphatidylglycerol , palmitic acid , phosphatidylserine , phosphatidylethanolamine , phosphatidylcholine , chemistry , phosphatidylinositol , phospholipid , stearate , biochemistry , chromatography , fatty acid , organic chemistry , kinase , membrane
The incorporation of [ 3 H]palmitic acid and [ 14 C]stearic acid into phospholipids in rabbit lung tissue was studied. Under equal molar concentrations of palmitate and stearate, palmitate was incorporated to the 1‐ and 2‐positions of phosphatidylcholine (PC) and phosphatidylglycerol (PG) 2–3 times more than stearate. By contrast, palmitate was 30% less than stearate in phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine. These results suggest that preferential utilization of palmitate over stearate, rather than substrate availability, determines the high content of palmitoyl at the 1‐ and 2‐positions of PC and PG in lung.