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The influence of vitamin E and selenium on lipid peroxidation and aldehyde dehydrogenase activity in rat liver and tissue
Author(s) -
Lee HyeSung,
Csallany A. Saari
Publication year - 1994
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537188
Subject(s) - lipid peroxidation , aldehyde dehydrogenase , malondialdehyde , vitamin e , chemistry , lipidology , endocrinology , medicine , biochemistry , in vivo , clinical chemistry , antioxidant , biology , enzyme , microbiology and biotechnology
Malondialdehyde (MDA) production and cytosolic aldehyde dehydrogenase (ALDH) response were examined in rat liver tissues after feeding different levels of dietary vitamin E and/or selenium and polyunsaturated fat for 12–38 wk. MDA production was significantly increased by vitamin E deficiency or by high levels of polyunsaturated fat intake, but not by selenium deficiency. The activity of cytosolic ALDH increased upon increased production of MDA after 12–16 wk of feeding the lipid peroxidation‐inducing diets. However, ALDH activity was suppressed after 38 wk of feeding the vitamin E‐deficient diet. The results indicate that the hepatic cytosolic ALDH may be involved in the metabolism of MDA during a relatively short‐term increase in in vivo lipid peroxidation, but that ALDH activity becomes suppressed after more severe in vivo lipid peroxidation has been produced. Hepatic and plasma α‐tocopherol levels and lipid peroxidation products were measured for the various dietary groups.