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On the effect of peroxisomal β‐oxidation and carnitine palmitoyltransferase activity by eicosapentaenoic acid in liver and heart from rats
Author(s) -
Aarsland Asle,
Lundquist Morten,
Børretsen Bernt,
Berge Rolf K.
Publication year - 1990
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537162
Subject(s) - eicosapentaenoic acid , peroxisome , triglyceride , carnitine , medicine , chemistry , endocrinology , beta oxidation , fatty acid , clinical chemistry , lipidology , carnitine palmitoyltransferase i , biochemistry , cholesterol , biology , polyunsaturated fatty acid , receptor
Repeated administration of highly purified eicosapentaenoic acid (as ethyl ester) resulted in a decrease in plasma triglycerides and high density lipoprotein (HDL) cholesterol. This was accompanied by a stimulation in the activities of carnitine palmitoyltransferase, fatty acyl‐CoA oxidase and peroxisomal β‐oxidation in the liver. The results suggest that the triglyceride‐lowering effect observed with eicosapentaenoic acid may be due to a reduced supply of fatty acids for hepatic triglyceride synthesis because of increased fatty acid oxidation. Eicosapentaenoic acid feeding marginally affected the triglyceride content of heart and mitochondrial and peroxisomal enzyme activities.