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Effects of dietary oil related to the toxic oil syndrome on the lipids of guinea pig liver microsomes
Author(s) -
Casa E.,
PérezGonzález N.,
SánchezBernal C.,
Llanillo M.
Publication year - 1995
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537033
Subject(s) - phospholipid , composition (language) , clinical chemistry , microsome , lipidology , palmitoleic acid , guinea pig , food science , arachidonic acid , chemistry , linoleic acid , palmitic acid , fatty acid , biochemistry , biology , endocrinology , enzyme , linguistics , philosophy , membrane
Abstract The potential effects of oil specimens related to cases of toxic oil syndrome (TOS) on the liver microsomal lipid composition from guinea pigs were investigated. For four weeks, animals were fed diets supplemented with either “case oil” (oil related to cases of TOS) or “control oil” (oil unrelated to cases of TOS), either previously heated or not. Results were compared with those from guinea pigs fed the same diet with no oil. The administration of case oil produced changes in liver microsomal lipid composition. Statistically significant differences were also found between heated case and heated control oils. The cholesterol/phospholipid molar ratios and the major phospholipid class distribution were unaffected under these diet conditions. However, increases in the relative contents of linoleic and arachidonic acids and, simultaneously, a reduction in palmitic and palmitoleic acid levels were observed by diet effects. Heated oil administration decreased the saturated/unsaturated ratios in all cases. Our data suggest that changes observed in the fatty acid composition are attributable to the free fatty acid contents of administered oils. The toxic constituents of case oil seem to be able to alter the liver microsomal lipid composition.