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9‐ cis β‐carotene in human plasma and blood cells after ingestion of β‐carotene
Author(s) -
Tamai Hiroshi,
Morinobu Takao,
Murata Takuji,
Manago Mitsuhiro,
Mino Makoto
Publication year - 1995
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02537022
Subject(s) - carotene , lipidology , clinical chemistry , ingestion , human plasma , food science , human blood , chemistry , beta carotene , medicine , chromatography , biochemistry , carotenoid , physiology
For 44 wk, thirty male volunteers were given daily either 60 mg of synthesized all‐ trans β‐carotene, a naturally‐occurring β‐carotene derived from Dunaliella bardawil , or a placebo. Basal levels of 9‐ cis β‐carotene in plasma, platelets, and mononuclear cells were 10, 20 and 25% of those of the all‐ trans form, respectively. The plasma levels reached a maximum after two weeks of administration and plateaued thereafter in the subjects who took the β‐carotene preparations. The all‐ trans β‐carotene level in the subjects given the synthesized all‐ trans form was almost twice that for the Dunaliella preparation. The plasma 9‐ cis level was found to be higher in the all‐ trans β‐carotene group than in the Dunaliella group, despite no intake of the 9‐ cis form in the all‐ trans group and the higher intake of the 9‐ cis form in the Dunaliella group. This finding suggests that isomerization of the all‐ trans form to the 9‐ cis form may occur in the body either during or after absorption.