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Serum fatty acid profiles in cystic fibrosis patients and their parents
Author(s) -
Christophe A. B.,
Warwick W. J.,
Holman R. T.
Publication year - 1994
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536629
Subject(s) - cystic fibrosis , heterozygote advantage , fatty acid , lipidology , clinical chemistry , medicine , obligate , biology , biochemistry , chemistry , endocrinology , gene , genotype , ecology
Fatty acid compositions of the major serum lipid classes from 43 cystic fibrosis (CF) homozygotes (CF patients), 36 obligate heterozygotes (parents of CF patients) and 34 controls were determined by capillary gas chromatography. Fatty acid compositions of the homozygote CF patients were skewed in the direction of relative essential fatty acid deficiency in comparison with the controls. Less pronounced, but similar deviations from normal, were observed in the heterozygotes. Homozygotes with normal fatty acid compositions and heterozygotes with considerably disturbed fatty acid profiles were found.