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Effect of marine oils supplementation on coagulation and cellular activation in whole blood
Author(s) -
Østerud Bjarne,
Elvevoll Edel,
Barstad Harald,
Brox Jan,
Halvorsen Hanne,
Lia Karin,
Olsen Jan Ole,
Olsen Ragnar L.,
Sissener Charlotte,
Rekdal Øystein,
Vognild Eva
Publication year - 1995
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536611
Subject(s) - blubber , cod liver oil , whale , minke whale , cholesterol , lipidology , zoology , food science , medicine , chemistry , biology , biochemistry , fishery , balaenoptera
A study was performed to explore the effects of supplemental intake of various marine oils known to be part of the Eskimo diet. Healthy men and women (134) were randomly selected to consume 15 mL/d of oil from blubber of seal, cod liver, seal/cod liver, blubber of Minke whale, or no oil for ten weeks. Total cholesterol was unchanged in the oil groups, whereas high density lipoprotein cholesterol increased 7% in the seal/cod liver oil (CLO) group ( P <0.05) and 11% in the whale oil group ( P <0.005). Triacylglycerol was significantly reduced in the CLO group only. The concentration of prothrombin fragment 1+2 was reduced 25% ( P <0.05) after whale oil supplementation. No change in fibrinogen or factor VIIc was detected. Tumor necrosis factor generation in lipopolysaccharide (LPS)‐stimulated blood was 30% reduced after whale oil ( P <0.05), but was unaffected by intake of seal or CLO. The LPS‐induced tissue factor activity in monocytes was reduced to a significant degree only in the seal/CLO group (34%) and whale oil group (35%) ( P <0.05). The most dramatic change in thromboxane B 2 in LPS‐stimulated blood was seen after whale oil intake with 44% reduction ( P <0.01). Supplementation of a regular diet with a combination of seal oil and CLO and especially with whale oil seems to have beneficial effects on several products thought to be associated with cardiovascular and thrombotic diseases.