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Effect of PAF‐acether antagonists on active anaphylactic mouse paw edema
Author(s) -
Amorim Claudia Zuany,
Oliveira Henriques Maria das Graças Muller,
Weg Vivian Baseches,
Balão Cordeiro Renato Sérgio,
Vargaffig B. Boris
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536574
Subject(s) - ovalbumin , anaphylaxis , anaphylactic reaction , aspirin , chemistry , edema , cyclooxygenase , pharmacology , methysergide , allergy , medicine , immunology , antigen , biochemistry , antagonist , receptor , enzyme
A new model of active anaphylactic reaction in mice was developed. The edematogenic reaction appeared 5 min after the intraplantar injection of ovalbumin, peaked at 30 min after the antigenic challenge, and decreased there‐after. Using the non‐steroidal, anti‐inflammatory agents indomethacin and aspirin, we found that cyclooxygenase products do not participate in the reaction. In contrast, vasoactive amines appear to be involved, because meclizine and methysergide reduced the edema. Dexamethasone, BW755C, LY 171883 and WEB 2170 effectively interfered with the edematogenic reaction, which suggests that lipid mediators such as leukotrienes and PAF play a role in the active anaphylactic response.