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The effect of CV‐3988 and CV‐6209 on the acute gastric erosions of rats due to water‐immersion and restraint stress
Author(s) -
Nogami Makoto,
Hoshihara Yoshio,
Tsubura Kunihiko,
Yamamoto Takashi,
Tabuchi Masafumi,
Miyamoto Terumasa,
Shiga Junji
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536565
Subject(s) - chemistry , immersion (mathematics) , prostaglandin , clinical chemistry , medicine , platelet activating factor , endocrinology , pharmacology , biochemistry , mathematics , pure mathematics
Abstract CV‐3988 and CV‐6209 inhibited gastric erosions in rats due to water‐immersion and restraint stress in a dose‐dependent manner. The above inhibitory effects of CV‐3988 were observed in the presence of indomethacin, which may indicate that the inhibition is not prostaglandin dependent. The studies indicate that platelet‐activating factor may be involved in the formation of erosions in rats under water‐immersion and restraint stress.