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Hypoxia, PAF, and necrotizing enterocolitis
Author(s) -
Caplan Michael S.,
Sun XiaoMing,
Hsueh Wei
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536562
Subject(s) - necrotizing enterocolitis , hypoxia (environmental) , platelet activating factor , pathophysiology , medicine , mediator , enterocolitis , immunology , gastroenterology , chemistry , oxygen , organic chemistry
Necrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet‐activating factor (PAF) on intestinal blood flow and intestinal necrosis, and implicate PAF as an important mediator in hypoxia‐induced intestinal injury. Finally we provide evidence that PAF may be important in neonatal NEC.