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Significance of platelet‐activating factor in mesenteric ischemia‐reperfusion
Author(s) -
Filep János,
Braquet Pierre,
Mózes Tibor
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536561
Subject(s) - platelet activating factor , circulatory system , ischemia , medicine , mesenteric ischemia , mesentery , anesthesia , platelet , cardiology , pathology
Reperfusion of the ischemic mesenterium is frequently followed by acute circulatory collapse. This review focuses on the possible role of platelet‐activating factor (PAF) in ischemia‐induced damage. It provides evidence that (i) PAF concentrations are elevated in the mesenteric circulation following temporary ischemia; (ii) administration of exogenous PAF into the superior mesenteric vein mimics many events observed during reperfusion; and (iii) pretreatment of the experimental animals with specific PAF receptor antagonists prevent the circulatory collapse. These findings suggest that PAF may play an important role in the development of circulatory collapse caused by mesenteric ischemia‐reperfusion.