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Effect of platelet‐activating factor on cortisol and corticosterone secretion by perfused dog adrenal
Author(s) -
Aikawa Tadaomi,
Hirose Taeko,
Matsumoto Itsuro,
Morikawa Toshiko,
Shimada Toshio,
Mine Yumi,
Tsujimoto Yoshiki,
Tsuji Yoshiro
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536511
Subject(s) - platelet activating factor , medicine , endocrinology , corticosterone , histamine , chemistry , secretion , platelet , phosphocholine , clinical chemistry , phospholipid , biochemistry , hormone , membrane , phosphatidylcholine
Administration of platelet‐activating factor (PAF) to perfused adrenal increased cortisol and corticosterone secretion. With hexadecyl PAF (C 16 PAF; 1‐ O ‐hexadecyl‐2‐acetyl‐ sn ‐glycero‐3‐phosphocholine), the increase was significant at 1 nM and maximal at 10 nM. The responses to 10 nM octadecyl PAF (C 18 PAF; 1‐ O ‐octadecyl‐2‐acetyl‐ sn ‐glycero‐3‐phosphocholine) were one fourth of those to 10 nM C 16 PAF. The addition of C 16 PAF to dispersed adrenal cells significantly increased cortisol and corticosterone production at 0.1 nM and 10 nM, respectively. C 16 PAF was about 1000 times more potent than histamine on a molar basis in respect to cortisol response in both perfused adrenal and dispersed adrenal cells. The results suggest that PAF induces cortisol release from dog adrenal.