Premium
Effect of ethanol on platelet phospholipase A 2
Author(s) -
Stubbs Christopher D.,
Rubin Raphael
Publication year - 1992
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536471
Subject(s) - arachidonic acid , phospholipase a2 , phospholipase , ethanol , cytosol , chemistry , platelet , secretion , phospholipase a , biochemistry , phospholipase c , enzyme , biology , immunology
Abstract Platelet aggregation is known to be inhibited by ethanol, and this has been suggested to be one of the attenuating effects of ethanol in cardiovascular disease. Recent studies have implicated an inhibition of phospholipase A 2 induced arachidonic acid release, since the production of prostanoids that are formed from arachidonic acid and are involved in the aggregation process has been shown to be diminished by ethanol. Phospholipase A 2 is found in platelets in both a cytosolic form, from where it may translocate to the plasma membrane to release arachidonic acid, and in a secretory form which is released extracellularly upon activition. In the present study, the effect of ethanol on the secretion of phospholipase A 2 and on its activity was determined. It was found that ethanol inhibited trast, the activity of the cytosolic form of phospholipase A 2 was inhibited by ethanol.