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Effects of eicosatetraynoic acid on membrane lipids of trout liver and intestine
Author(s) -
Pelletier X.,
Leray C.
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536450
Subject(s) - lipidology , trout , clinical chemistry , medicine , food science , fatty acid , biology , biochemistry , chemistry , endocrinology , fish <actinopterygii> , fishery
After two months feeding either an (n‐3) or an (n‐6) fatty acid‐rich diet, two groups of trout were switched to the (n‐6) or the (n‐3) fatty acid‐rich diet, respectively. Half of each group was treated with 0.03% 5,8,11,14‐eicosatetraynoic acid (ETYA) in the diet. Liver and intestinal brush border membrane lipids were analyzed. No effect was observed on their cholesterol content. ETYA induced an accumulation of 18∶2(n‐6), and it did not affect the 20∶4(n‐6) content but decreased the 22∶5(n‐6) content. ETYA induced an increase of 18∶3(n‐3) content in the brush border membrane and a decrease of the 22∶6(n‐3) content in the liver. Those results suggest that ETYA blocks mainly the Δ6‐desaturase, which should have two different sites in the liver and one in the intestine.