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Sterol biosynthesis inhibitors: Their current status and modes of action
Author(s) -
Mercer E. I.
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536422
Subject(s) - squalene , sterol , biosynthesis , enzyme , biochemistry , mechanism of action , chemistry , lipidology , squalene monooxygenase , mechanism (biology) , clinical chemistry , stereochemistry , biology , cholesterol , philosophy , in vitro , epistemology
The mechanism of each of the reactions in the post‐squalene segment of the fungal and higher plant sterol biosynthetic pathway is outlined. The inhibitors of the enzymes catalyzing the reactions are described and how inhibition is brought about is explained in the areas where it is known.