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Effects of high levels of dietary fats on the growth of azaserine‐induced foci in the rat pancreas
Author(s) -
Roebuck B. D.
Publication year - 1986
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536413
Subject(s) - azaserine , lipidology , clinical chemistry , pancreas , food science , chemistry , medicine , biology , endocrinology , biochemistry , glutamine , amino acid
Azaserine induced two phenotypically different populations of foci, namely, acidophilic and basophilic foci. The effects of dietary modification during the post‐initiation phase of carcinogesis were examined. A diet of 20% (w/w) unsaturated fat (unsat) compared to a 20% saturated fat (sat) diet or a control diet (5% unsaturated fat) increased the number of acidophilic foci, as well as the thymidine labeling index (LI) of their nuclei. While the basophilic foci are carcinogen‐induced and at 2.5 mo post‐initiation have a similarly high growth rate to the acidophilic foci, this rate is not sustained as indicated by examination of both the LI and mean size of foci at 4 mo post‐initiation.