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Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents
Author(s) -
Das Arun K.,
Holmes Ronald D.,
Wilson Golfer N.,
Hajra Amiya K.
Publication year - 1992
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536379
Subject(s) - ether , plasmalogen , lipidology , clinical chemistry , glycerol , chemistry , biochemistry , medicine , endocrinology , phospholipid , biology , organic chemistry , membrane
Abstract Chronic feeding of 1‐ O ‐octadecyl‐ sn ‐glycerol (batyl alcohol) to patients suffering from congenital deficiency in tissue ether glycerolipids showed an increase in the plasmalogens content of their erythrocytes. However, nothing is known about the ether lipid content of other tissues in these patients. Feeding 1‐ O ‐heptadecyl‐ sn ‐glycerol to young rats showed that this uncommon ether lipid was incorporated to a high extent into the plasmalogens of all tissues except brain. Comparative studies with other precursors, such as 3‐ O ‐heptadecyl‐ sn ‐glycerol, heptadecanol and heptadecanoic acid, indicated a stereospecific incorporation of the dietary 1‐ O ‐alkyl‐ sn ‐glycerols into tissue plasmalogens without cleavage of the ether bond. Dietary ether lipids were also shown to be transferred from mothers to suckling rats, but not from pregnant rats to fetuses. The implication of these results to possible dietary ether lipid therapy for patients suffering from peroxisomal disorders is discussed.