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Effects of estrogen‐induced hyperlipidemia on the erythrocyte membrane in chicks
Author(s) -
Simon Cho B. H.,
Smith Terrance L.,
Park Jeong R.,
Kummerow Fred A.
Publication year - 1988
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536204
Subject(s) - erythrocyte fragility , medicine , lipid peroxidation , endocrinology , chemistry , hyperlipidemia , phospholipid , oleic acid , vitamin e , thiobarbituric acid , estrogen , fatty acid , triglyceride , linoleic acid , cholesterol , biochemistry , antioxidant , biology , hemolysis , membrane , diabetes mellitus
The effects of estrogen‐induced hyperlipidemia on plasma lipid peroxidation, fatty acid composition and osmotic fragility of erythrocytes in chickens were studied. Young male chickens implanted with estrogen for three wk developed a marked hyperlipidemia. Plasma levels of triglyceride, cholesterol and phospholipid were elevated 68‐, four‐ and 24‐fold, respectively, over controls. There was also a two‐fold increase in plasma lipid peroxidation measured by the thiobarbituric acid test. Vitamin E supplement (1,000 IU/kg diet) reduced the plasma lipid peroxidation to the control level, but had no effect on the plasma lipid content. Estrogen‐induced hyperlipidemia resulted in changes in the fatty acid composition of membrane lipids of erythrocytes. The major changes were an increase in oleic acid from 10.0% to 14.2% and a decrease in linoleic acid from 31.3% to 26.0%. The erytrocytes with an altered membrane fatty acid composition were found to have an increased osmotic fragility. It was apparent that there was a direct correlation between the oleic acid content and the osmotic fragility of erythrocytes.