Premium
Inhibition of ferrous‐induced lipid peroxidation by pyrimido‐pyrimidine derivatives in human liver membranes
Author(s) -
Cruz J. P.,
Carrasco T.,
Ortega G.,
Cuesta F. Sanchez
Publication year - 1992
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536177
Subject(s) - lipid peroxidation , chemistry , biochemistry , ferrous , lipidology , pyrimidine , clinical chemistry , ascorbic acid , antioxidant , pharmacology , biology , organic chemistry , food science
The effects of pyrimido‐pyrimidine derivatives (dipyridamole, RA‐642, and RA‐233) on lipid peroxidation, using d‐α‐tocopherol as standard, were studied in enriched membrane fractions from human and rat hepatocytes. Equimolar concentrations of ferrous sulfate and ascorbic acid were used to induce lipid peroxidation. The amount of peroxidized lipids observed in membrane fractions from human liver was smaller than in those from rat liver. In both species, however, pyrimido‐pyrimidine derivatives, except for RA‐233 in rat liver, inhibited lipid peroxidation dose‐dependently in the following sequence: RA‐642 > dipyridamole > d‐α‐tocopherol RA‐233.