Premium
Nonesterified fatty acids in normal and diabetic rat sciatic nerve
Author(s) -
Chattopadhyay Jyotiprakas,
Thompson Ed W.,
Schmid Harald H. O.
Publication year - 1992
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536133
Subject(s) - nefa , endoneurium , phosphatidylethanolamine , medicine , endocrinology , clinical chemistry , phospholipid , chemistry , sciatic nerve , lipidology , alloxan , diabetes mellitus , phosphatidylinositol , biochemistry , fatty acid , phosphatidylcholine , membrane , kinase
Abstract Alloxan‐induced diabetes in rats results in elevated levels of nonesterified fatty acids (NEFA) in whole sciatic nerve and its endoneurium. Increases in NEFA levels are more pronounced in whole diabetic nerve (40% over control) than in its endoneurial portion (20–30%). Alterations in the composition of phospholipid fatty acids are observed as well, including an increase in linoleate (18∶2n−6) in endoneurial phosphatidylethanolamine and a decrease in arachidonate (20∶4n−6) in both phosphatidylethanolamine and phosphatidylinositol of diabetic nerve.