Nonesterified fatty acids in normal and diabetic rat sciatic nerve | Zendy

Chattopadhyay Jyotiprakas | Zendy; Thompson Ed W. | Zendy; Schmid Harald H. O. | Zendy

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Nonesterified fatty acids in normal and diabetic rat sciatic nerve

Author(s) -

Chattopadhyay Jyotiprakas,

Thompson Ed W.,

Schmid Harald H. O.

Publication year - 1992

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/bf02536133

Subject(s) - nefa , endoneurium , phosphatidylethanolamine , medicine , endocrinology , clinical chemistry , phospholipid , chemistry , sciatic nerve , lipidology , alloxan , diabetes mellitus , phosphatidylinositol , biochemistry , fatty acid , phosphatidylcholine , membrane , kinase

Alloxan‐induced diabetes in rats results in elevated levels of nonesterified fatty acids (NEFA) in whole sciatic nerve and its endoneurium. Increases in NEFA levels are more pronounced in whole diabetic nerve (40% over control) than in its endoneurial portion (20–30%). Alterations in the composition of phospholipid fatty acids are observed as well, including an increase in linoleate (18∶2n−6) in endoneurial phosphatidylethanolamine and a decrease in arachidonate (20∶4n−6) in both phosphatidylethanolamine and phosphatidylinositol of diabetic nerve.

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